古くて新しい乳頭腫の研究についての続き。お勧めされた文献の紹介です。現在までに13のウイルスが同定されており、皮膚から消化器系、膀胱において乳頭腫の発生が認められているのだそうな。免疫抑制状態やワラビを食べていたりすると腫瘍になりやすい。種特異性が強いけど、宿主の種を超えて感染するウイルスも数種確認されている。他の文献では、同一農家の猫と牛の乳頭腫が同じウイルスだったと報告されている。
Bocaneti F, Altamura G, Corteggio A, Velescu E, Roperto F, Borzacchiello G
Transbound Emerg Dis 2016 Feb;63(1):14-23
PMID: 24661978
Abstract
Bovine papillomaviruses (BPVs) are small DNA tumoral viruses able to induce benign cutaneous and/or mucosal epithelial lesions. Generally, the benign tumours affecting the skin or mucosa spontaneously regress, but under special circumstances, the defence system may be overwhelmed, thus leading to cancer, especially in the presence of immunosuppressant and mutagen agents from bracken fern. To date, thirteen different BPV genotypes have been associated with skin and mucosal tumours in cattle, and out of these, only four types (BPV-1, -2, -5 and -13) cross-infect other species. Recent investigations in vivo have revealed new insights into the epidemiology and pathogenesis of this viral infection. This review briefly discusses viral epidemiology, will give data on BPV genome structure and viral genes and will describe the cellular events and new aspects of both cutaneous and mucosal tumours in large ruminants. Finally, some aspects of active immunization will be described.