Losco PE, Leach MW, Sinha D, Davis P, Schmahai TJ, Nomier A, Kakkar T, Reyderman L, Lynch ME
Toxicol Pathol 2007 Feb;35(2):310-22
PMID: 17366326
Abstract
SCH 206272, an antagonist of neurokinin receptors 1, 2, and 3, was administered orally by gavage for 1 month to 8- to 10-month-old dogs at doses of 0, 15, 30, or 60 mg/kg, and to 6-week-old rats at doses of 0, 30, 100, or 300 mg/kg. The most important changes occurred in the reproductive tract of the dogs at all doses. Absolute and relative group mean organ weights for the testes, prostate gland, epididymides, ovaries, and uterus were 33-86% lower than concurrent controls in groups receiving SCH 206272. Organ weight changes were not dose-related. Microscopic changes that correlated with the organ weight changes occurred in all groups receiving SCH 206272. For males, they included minimal to severe atrophy of the testes, epididymides, and prostate gland. In addition, the epididymides exhibited severe oligospermia or aspermia, minimal epithelial apoptosis and mild epithelial vacuolation. In female dogs, the ovaries and uteri appeared immature. Microscopic changes were similar in incidence and severity in dogs receiving 30 or 60 mg/kg, but were slightly less in dogs receiving 15 mg/kg. In contrast, similar findings were not observed in the reproductive tract of male or female rats, despite overlapping systemic, hypothalamic, and pituitary gland concentrations of SCH 206272.
gavage: 経管栄養, 胃管栄養, 胃管栄養法
concurrent: 同時発生的な, 同時的な, 一致した, 同時の, 併用の
oligospermia: the condition of having less than the normal number of spermatozoa in the semen: a cause of infertility in men 精子減少症 , 精液過少症
vacuolation: A small extracellular cavity or space within tissues. 空胞化, 空胞形成
discrepancy: Divergence or disagreement, as between facts or claims; difference. (陳述・計算などの)矛盾，不一致，食い違い